With the elucidation of the relevant mechanisms, the targets in the pyroptosis-related signaling pathways are expected to become a new hotspot in the treatment of DKD, and targeting pyroptosis through inflammasome assembly, caspase activation, GSDMD-mediated nuclear pore formation, and other unknown upstream or downstream pathways may be a new way to treat DKD. This evidence concerns the gene GSDMD and diabetic kidney disease.