YTHDC2 and colorectal carcinoma: Further, YTHDC2 was significantly correlated with multiple immune cell infiltrations, and the expression of YTHDC2 gene in the high-TMB group was found to be significantly higher than that in the low-TMB group; hence, we inferred that it might be correlated with the efficacy of immunotherapy; unfortunately, it was not found after the validation using IMvigor210 dataset; the reason might be that this external dataset was not from CRC.