For the innate immune system, (1) DM affects the polarization of macrophages and reduces the ability of macrophages to present antigens and clear TB; (2) the decrease of cytokines such as IL-22 and IL-8 in TB-DM leads to the decrease of phagocytosis and bactericidal activity of neutrophils; (3) the inhibition of adaptive immunity leads to the increase of NK cells, but its specific effect is not clear; and (4) the decrease of DCs frequency reduces the antigen presentation, resulting in adaptive immune dysfunction. The gene discussed is IL22; the disease is tuberculosis.