PRRT2 and Hyperglycemia: When the blood glucose concentration increases, the microvascular endothelial cells down-regulate the glucose transport rate, leading to intracellular hyperglycemia (7, 8) and a series of critical downstream pathways such as polyol pathway flux, elevated AGEs, elevated expressing of AGEs receptors and their activation ligands, stimulation of PKC subtypes and aminohexose signal path (9–11).