Proteomic analyses have revealed that arginase 1 (Arg1) is increased significantly, and it has been proven that serum exosomes deliver Arg1 to endothelial cells (185). In STZ-induced diabetic nephropathy rats, platelets with elevated CXCL7 expression can activate the mTORC1 pathway and result in glomerular endothelial dysfunction (186). This evidence concerns the gene ARG1 and diabetic kidney disease.