Recent findings show that NOTCH1 signaling in retinal microvascular endothelial cells induces vascular permeability in diabetes: NOTCH1 ligands JAGGED1 and DELTA LIKE-4 are secondary to hyperglycemia and activate the canonical and rapid atypical NOTCH1 pathways, ultimately disrupts adherent junctions between endothelial cells by causing diabetic endothelial dissociation (142). Here, NOTCH1 is linked to Hyperglycemia.