Inflammation of the pancreas destroys the parenchyma in pathophysiological conditions, and persistent inflammatory response leads to the exocrine pancreatic insufficiency, in which the production of pancreatic enzymes is greatly reduced and thus insulin secretion is released from the inhibitory effect of exocrine enzymes that leads to hyperinsulinemia which has been considered to be responsible for the development of insulin resistance (30). The gene discussed is INS; the disease is hyperinsulinism.