In the setting of severe hypertriglyceridemia, restricted blood flow and accumulations of FFA could lead to impairment of circulation in capillary beds, ischemic disturbance to the acinar structures, and a resultant increasingly acidic environment, in which the pancreatic lipase could more easily seep out of acinar cells and be activated by FFA to cause additional pancreatic injury (12). Here, PNLIP is linked to hypertriglyceridemia.