Another study showed that obesity-associated adipokine leucine-rich alpha-2-glycoprotein 1 (LRG1) bound with high selectivity to the liver and exacerbated high fat diet-induced hepatosteatosis and IR by increasing de novo lipogenesis and suppressing fatty acid β-oxidation (37). This evidence concerns the gene LRG1 and obesity due to melanocortin 4 receptor deficiency.