GSDMD and familial dilated cardiomyopathy: Indeed, a recent study found a reduction in METTL14 levels and an increase in the levels of pyroptosis-related markers, including caspase-1, the N-terminus of GSDMD (GSDMD-N), and NLRP3, in both rats with DCM and high glucose (HG)-treated cardiomyocytes (182).