TNF and cardiac hypertrophy: LC was also able to improve LV systolic and diastolic function, enhance myocardial output, and reverse LV remodeling via the reduction of myocardial infarct size and suppression of myocardial hypertrophy, The inflammatory levels of TNF-α, IL-1β, and IL-6 were significantly increased in post-MI mice, which were blunted by LC treatment as well.