LGALS3 and Myocardial fibrosis: Previous studies have also demonstrated that ALD-activated macrophages play a major role in cardiac myofibrosis by promoting the secretion of Gal-3 and Gal-3 was required for the inflammatory and fibrotic reactions induced by ALD, which suggest that there is an interaction between Gal-3 and aldosterone in myocardial fibrosis [20, 21].