Moreover, previous studies have shown that LSM1 is highly associated with PIK3CA and BCL‐2 in regulating the chemotherapy resistance pathway in small cell lung cancer and ‘IGF‐1 receptor/EGFR synergy in lung cancer’, suggesting that LSM1 plays an important role with PIK3CA in lung cancer tumour progression.24 This evidence concerns the gene PIK3CA and lung carcinoma.