Our current study firstly analyzed the relationship between 51 mitophagy-related genes and the prognosis of GBM in TCGA cohort and constructed a mitophagy-related prognostic predicting model containing 4 genes (MAP1LC3A, TOMM20, PHB2, UBA52), which was validated well in external databases. The gene discussed is MAP1LC3A; the disease is glioblastoma.