Microglia-astrocyte crosstalk and microglia-neuron crosstalk have been reported to be critical in the pathology of AD by modulating clearance of Aβ/tau and neuronal survival.32–34 Since microglia originate from the mesoderm lineage and other CNS cells are derived from neuroectodermal progenitors, most cerebral organoids generated by classical protocols lack the integration of microglia. The gene discussed is MAPT; the disease is Alzheimer disease.