Spastic paraplegia (SPG) type 11, profilin 1, never in mitosis gene A-related kinase 1 (NEK1), tubulin 4a, NFH, and chromosome 21 open reading frame 2 (C21ORF2 or CFAP410) have been identified as ALS-causing and susceptibility genes involved in axonal pathology and cytoskeletal abnormalities by ancestry analysis and GWASs [25, 100, 173]. The gene discussed is PFN1; the disease is amyotrophic lateral sclerosis.