The development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it.2 Vascular Endothelial Growth Factor-A (VEGF-A) is a key regulator of tumour-induced angiogenesis and essential for tumour growth and distant tumour spread.3 Thus, VEGF can be a potential target to limit distant spread of the tumour. The gene discussed is VEGFA; the disease is neoplasm.