ASPG and hepatocellular carcinoma: In addition, asparaginase described by Shafei et al.[48] blocked the proliferation of three human carcinoma cell lines, including prostate carcinoma (PC3; IC50 ~37 μg/ml), breast carcinoma (MCF7; IC50 ~ 12.5 μg/ml), and hepatocellular carcinoma (Hep-G2; IC50 ~14 μg/ml).