Increased activity of other gene sets related to microglial state and function, such as cholesterol metabolism, glycolysis, phagocytic and lysosomal function resembled those observed in microglia from the 5xFAD transgenic or demyelination models [14, 22, 43] (Fig. 3c), demonstrating that some aspects of the microglia signature are conserved across diverse APP mouse models, including the AppSAA KI mouse model. This evidence concerns the gene APP and Peripheral demyelination.