SPP1 and Alzheimer disease: Finally, the upregulation of the signature genes (Spp1, Tmem163, Apoe, Ctsb, Hif1a, among others) from the Mic1 microglia sub-cluster in human AD [19] were enriched in the phagocytic microglia from the AppSAA homozygous mice (p-value < 1e-4, hypergeometric test; Fig 4i), suggesting that this mouse model successfully recapitulates a subset of the microglial response found in human disease.