vWF:Ag had moderate diagnostic accuracy in discriminating patients with severe/necrotizing AP from patients with non-severe edematous AP in the prospective cohort (AUROC 0.750; 95% CI 0.624–0.876) and in the ICU cohort (AUROC 0.718; 95% CI 0.569–0.866) on day 1, which was even higher at day 3 (AUROC 0.829; 95% CI 0.705–0.952). Here, VWF is linked to alkaline phosphatase measurement.