Tumor intrinsic pathways that correlated with ICR score in these tumors (Supplementary Fig. 3A) are TNFR1, PI3K Akt mTOR signaling, Immunogenic cell death, Apoptosis, mTOR and others, while signatures inversely correlated with survival in both tumors include barrier genes, mismatch repair, proliferation, G2M checkpoints. The gene discussed is MTOR; the disease is neoplasm.