INS and chronic kidney disease: In a small, non-randomized study, 89 patients with T2DM and CKD (mean GFR 34.1 ± 11.5 mL/min/1.73 m2) with poorly controlled or that had frequent hypoglycemia with oral agents or NPH insulin, received insulin Glargine at bedtime, starting with 0.1 U/kg and later being titrated.