In a prospective evaluation, the albumin concentration ≥ 14 mg/L in a urine sample increased approximately threefold the risk of CV events (HR 3.25; 95% CI 1.43—7.38; p = 0.005) four times the risk of DKD (HR 4.3; 95% CI 2.22—8.32; p < 0.001) and five times the risk of death (HR 5.51; 95% CI 1.16—26, 22; p = 0.032), which indicates that even values ​​below the mentioned cutoff can predict cardiorenal outcomes [29]. This evidence concerns the gene ALB and diabetic kidney disease.