Female, waist circumference ≥ 90 cm, diabetes, FG ≥ 88 mg/dL, triglyceride ≥ 160 mg/dL, HDL-C ≤ 0.8 mmol/L, LDL-C ≥ 2.0 mmol/L and apolipoprotein B ≥ 0.70 g/L may be the risk factors of obesity. This evidence concerns the gene APOB and obesity due to melanocortin 4 receptor deficiency.