BSG and liver cancer: To confirm proper expression of both endogenous mouse CD147 and knock-in human CD147 in hCD147KIhet-NSG mice, we first assessed antibody specificities against CD147 to preclude any cross-reactions between human and mouse tissues by testing them against the human liver cancer cell line HepG2 and the mouse liver cancer cell line BNL 1ME A.7R.1 (Additional file 1: Figure S2).