Mesenchymal transition from another subtype is associated with highly elevated levels of tumor-associated macrophages (TAMs) and tumor-infiltrating T cells [31]; the upregulation of the NF-κB pathway via increased TNF-α (tumor necrosis factor-α) signaling in the TME; and deactivation of NF1 [26, 32]. The gene discussed is TNF; the disease is neoplasm.