Among patients with advanced HCC, RT + anti-PD1 therapy may be associated with significantly better PFS, PR rate, ORR and DCR than TACE + sorafenib, as well as better OS among subgroups of patients in BCLC stage C, or with macrovascular invasion or AFP ≥ 400 ng/ml. Here, PDCD1 is linked to hepatocellular carcinoma.