For example, m6A RNA methylation regulators contribute to COPD progression, and the expressions of m6A RNA methylation regulators (IGF2BP3, FTO, METTL3, and YTHDC2) [35], which have significant associations with some key genes enriched in the signaling pathway and biological processes that promote the development progression of COPD, are highly correlated with the occurrence of COPD [36, 37]. Here, METTL3 is linked to chronic obstructive pulmonary disease.