SIRT1 and chronic obstructive pulmonary disease: For instance, SIRT1/p53 and FOXO3a signaling pathways mediated by senescence-associated lncRNA1 (SAL-RNA1) regulate the expression of SIRT1 and FOXO3a, promoting the senescence of type II alveolar epithelial cells (AECII) in the pathogenesis of COPD [14].