After treatment with different oxygen concentrations, Western Blot test results showed that compared with normoxia, the levels of LC3-II/LC3-I and Beclin-1 in RA-FLSs and OA-FLSs induced by hypoxia increased, while compared with RA-FLSs, LC3-II/LC3-I and Beclin-1 increased in OA-FLSs at a lower level (Fig. 3C). This evidence concerns the gene BECN1 and rheumatoid arthritis.