In fact, the disorder of cell redox balance in the hypoxic RA-FLSs silenced by BNIP3 was accompanied by the accumulation of ROS and the decrease of MMP, while the redox balance of RA-FLSs in the hypoxic Ctr siRNA group remained stable (Fig. 6D–G). The gene discussed is BNIP3; the disease is rheumatoid arthritis.