The results shown that advanced age (HR 2.78, 95%CI 1.82–4.30), low body mass index (BMI < 18.5 kg/m2: HR 1.77, 95%CI 1.17–2.67), congestive heart failure (HR 2.81, 95%CI 1.58–4.98), time on HD before PD ≤ 3 months (HR 1.49, 95%CI 1.05–2.10), peritonitis (HR 2.02, 95%CI 1.36–3.01) were associated with the increased risk of technique failure.; while higher serum albumin (HR 0.93, 95%CI 0.89–0.96) and using employee medical insurance to pay medical expenses (HR 0.47, 95%CI 0.32–0.69) were associated with reduced risk. The gene discussed is ALB; the disease is peritonitis.