First, the analysis of transcriptomic data revealed 735 DEGs between iSMGCs and iSLGCs involved in cytokine–cytokine receptor interaction, the Jak–STAT signaling pathway, leishmaniasis, legionellosis, cysteine and methionine metabolism, the Hippo signaling pathway, proximal tubule bicarbonate reclamation, and ribosome (Fig. 5D and E). This evidence concerns the gene SOAT1 and legionellosis.