Asking if the higher Th2/1 hybrid proportions detected in blood of mature mice early during infection developed at the expense of GATA-3 single-expressing Th2 cells, we compared the phenotype of T helper cells isolated from mesenteric lymph nodes (mLN) and spleen at day 6 post infection and found comparable frequencies of classical Th2 cells in both age groups (Supplementary Fig. S2) Despite the comparable instruction of Th2 cells in mLN, fewer Th2 cells homed to the small intestine in mature mice. This evidence concerns the gene GATA3 and infection.