The IFN-γ-Th2/1 hybrid-susceptibility axis was also evident in comparing partially resistant BALB/c to fully susceptible C57BL/6 mice, the latter exhibiting stronger accumulation of Th1 at steady state, more robust Th2/1 differentiation upon infection and a significant rise in resistance upon blocking of early type 1 cytokine signals. Here, IFNG is linked to infection.