Furthermore, we showed that, irrespective of the pre-exposure to other infections, a high proportion of naïve T cells activated in primary H. polygyrus infection differentiates into GATA-3+ T-bet+ Th2/1 hybrid cells12 and that IFN-γ signals integrated along with IL-4Rα signaling are critical for the commitment to the Th2/1 hybrid phenotype13. This evidence concerns the gene IFNG and infection.