In addition, the results of the luciferase reporter assay revealed that transfection of miR-27a or miR-27b mimics dramatically reduced the luciferase activity of the WT PPARγ 3′UTR sequence but not that of the mutant PPARγ 3′UTR sequence in HNSCC cells (Fig. 5E). Here, PPARG is linked to head and neck squamous cell carcinoma.