TNF and Arthritis: In vivo experimental models, mouse arthritis [42], mouse-ear edema [43], mouse-paw edema [44], and rat colitis [45] support our findings; hence, phycocyanin, a biliprotein obtained from the microalgae Spirulina (Arthospira) maxima, exerts anti-inflammatory activity by reducing LTB4 levels, TNF-α, NO, and arachidonic acid metabolites involved in the inflammatory response [46].