Acquired mutations (K-RAS, N-RAS, BRAF, DIS3, FAM46C and TP53 genes), copy number aberrations (del(17p)/TP53, del(13) and 1q gain), NF-κB pathway mutation and MYC aberrations are recurrent secondary oncogenic events in MM, which are associated with disease progression (Colombo et al. 2015; Roy et al. 2018; Pinto et al. 2020). This evidence concerns the gene NRAS and Miyoshi myopathy.