Prominent and potential genes involved in the secondary oncogenic event such as NRAS, IRF4, IDH2, PSMB5 and APOBEC2 were found to be up-regulated whereas SP140, LTB and ATM were down-regulated in MM (Kuehl and Bergsagel 2012; Bolli et al. 2014; Walker et al. 2018; Allmeroth et al. 2021). This evidence concerns the gene IDH2 and Miyoshi myopathy.