To further explore the oncogenic role of TGR5 in pancreatic cancer, TUNEL assay was used for apoptosis detection.The results indicated that the proportions of TUNEL-positive PANC-1 and BXPC3 cells in SBI-115-treated-groups were higher than those in control groups (Fig. 3). The gene discussed is GPBAR1; the disease is pancreatic neoplasm.