GPBAR1 and cancer: Furthermore, the KEGG enrichment analyses showed the altered metabolites were significantly related to choline metabolism in cancer, tryptophan metabolism, glycerophospholipid metabolism, et al. The correlation analyses between TGR5 and the metabolism-related genes in GEPIA 2 also suggested that TGR5 was significantly correlated with the choline metabolism, tryptophan metabolism and glycerophospholipid metabolism in pancreatic cancer.