POLR2A and ependymoma: Here we describe a case of ependymoma in a 2‐year‐old male with a de novo pathogenic variant in POLR2A predicted to impair proper interaction of the subunit with transcription‐elongation factor TFIIS, whose function is required for back‐tracking of the enzyme due to elongation blocks or nucleotide misincorporation, and expected to result in an increased error and reduced elongation rates.