FLT4 and persistent truncus arteriosus: To determine whether such a modest lymphangiogenic response in male C57Bl/6 mice may still have protected against cardiac inflammation and/or decompensation after pressure-overload, we next investigated the impact of selective inhibition of lymphangiogenesis using a VEGFR3-blocking antibody, mF4-31C1.18 To not interfere with the initial response to the pressure-overload, administration of the blocking antibody, or non-specific rat IgG in TAC controls, was initiated at 1 week after surgery, and the treatment was then maintained throughout the 8-week study.