VEGFC and cardiac hypertrophy: Recently, another study reported on the beneficial effects of therapeutic lymphangiogenesis in a mouse TAC model.42 The authors surprisingly demonstrate that systemic daily injections of recombinant Vegfc, an inefficient therapeutic modality,8,10 potently stimulated cardiac lymphangiogenesis and almost completely prevented myocardial oedema, cardiac hypertrophy and dysfunction during pressure-overload.