FLT4 and persistent truncus arteriosus: Moreover, given that we only observed a tendency for an increase in myocardial water content in the anti-VEGFR3-treated TAC group, which suffered cardiac lymphatic rarefaction, we postulate that the main culprit of myocardial oedema in our model may be unrelated to lymphangiogenesis, and instead reflect blood vascular hyperpermeability in the heart resulting from increased coronary blood pressure, and reduced vascular barrier resistance, after aortic banding.