CRP and Crohn disease: In the Post Operative Crohn’s Endoscopic Recurrence [POCER] study, endoscopic monitoring and treatment of early disease recurrence reduced Crohn’s disease progression.7 Endoscopically identified disease recurrence and progression occur before clinical symptoms develop.7 Measurement of serum C-reactive protein [CRP] is insensitive for disease recurrence,8 partly because of the low disease burden with early recurrence and partly because some patients with active Crohn’s disease do not develop an elevated C-reactive protein with active disease.