Several mechanisms and signaling pathways have been found to be implicated in ENZA resistance of PC, for example, the alterations of the AR, transdifferentiation to neuroendocrine tumors, glucocorticoid receptor overexpression, DNA‐repair and PI3K pathway alterations.11, 12, 13, 14, 15, 16, 17, 19. This evidence concerns the gene NR3C1 and neuroendocrine neoplasm.