Several mechanisms and signaling pathways have been found to be implicated in ENZA resistance of PC, for example, the alterations of the AR, transdifferentiation to neuroendocrine tumors, glucocorticoid receptor overexpression, DNA‐repair and PI3K pathway alterations.11, 12, 13, 14, 15, 16, 17, 19. The gene discussed is AR; the disease is neuroendocrine neoplasm.