IGHE and food allergy: Food allergies can in turn be divided mainly into two categories: IgE-mediated forms, attributable to an initial sensitization process to certain proteins against which the immune system develops IgE class antibodies responsible for acute symptoms onset (usually within 2 hours of food intake); and non-IgE-mediated forms, characterized by the involvement of humoral and/or cellular components with a later onset (few hours to few days after food intake) and with pathophysiological mechanisms not yet fully defined.