They depend on the type of pathogenetic mechanism (FI vs IgE- or non-IgE-mediated or mixed forms of FA), involved food, quantity ingested, food preparation method (thermolabile and thermostable allergens), type of contained allergens, exposure mode (concomitant intake of drugs or physical exercise), specific factors of the host (age, eating habits, degree and type of sensitization, presence of other allergic diseases) and presence of any concomitant comorbidities (disorders that cause intestinal mucosa damage are to be considered conditions favoring sensitization and allergic reaction). Here, IGHE is linked to allergic disease.