Skin allergy tests (skin prick tests, SPT) are allergy screening tests commonly used to identify the presence of specific IgE for food allergens and are performed by placing a drop of the allergen extract on the skin (usually the volar portion of the forearm) and then pricking the skin, through the drop, with a metal lancet with a 1-mm disposable tip. The gene discussed is IGHE; the disease is allergic disease.