The expression level of p16 in the Detwiller's sarcoma database was up-regulated, and the multiple changes in these genes in leiomyosarcoma, pleomorphic liposarcoma, round cell liposarcoma, dedifferentiated liposarcoma, and malignant fibrous histiocytoma were 21.899, 25.731, 11.632, 4.897, and 4.789, respectively. The gene discussed is CDKN2A; the disease is leiomyosarcoma.