The expression level of p16 in the Detwiller's sarcoma database was up-regulated, and the multiple changes in these genes in leiomyosarcoma, pleomorphic liposarcoma, round cell liposarcoma, dedifferentiated liposarcoma, and malignant fibrous histiocytoma were 21.899, 25.731, 11.632, 4.897, and 4.789, respectively. Here, CDKN2A is linked to round cell liposarcoma.