ACE2 and obesity due to melanocortin 4 receptor deficiency: Overweight and obesity, common consequences of lockdown, have been considered as an independent risk factor for severe COVID-19; this has been related to endothelial dysfunction associated with metabolic syndrome, and the increased expression of angiotensin-converting enzyme 2 (ACE2) receptors, the entrance door for SARS-COV-2 into the cells [20].