NCAPD3 and colitis: By comparing with wild type (WT) mice, NCAPD3± mice exhibited less body weight loss during three times of DSS treatment (a, b and c sites of Fig. 7A) and had a higher body weight and the longer length of colorectum at the end of experiment (Fig. 7A, B), indicating that NCAPD3-deficient mice were less susceptibility to DSS-induced colitis than WT mice.