NCAPD3 and infectious otitis media: To confirm the effect of NCAPD3 on tumorigenesis, NCAPD3 knockout mice (NCAPD3± mice) was generated and identified by PCR analysis (Supplementary Fig. S5A, B); and the mouse model of colitis-associated colorectal cancer was established by intraperitoneally injecting with 10 mg/kg AOM and following by three cycles of 2% DSS drinking treatment (Supplementary Fig. S5C).