NCAPD3 higher expression in CRC cells could up-regulate the expression level of c-Myc and recruit more c-Myc to its downstream target glycolytic genes, such as GLUT1, HK2, ENO1, PKM2 and LDHA, and finally promoted colorectal carcinogenesis and CRC cell growth, proliferation, and metastasis by enhancing the aerobic glycolysis process. Here, HK2 is linked to colorectal carcinoma.