According to our signature, this phenotype was accompanied by a decrease in YAP1-TEAD-dependent transcription and was specific to the Hippo-deleted and YAP1-TEAD-activated MSTO-211H model since knockdown of YAP1 in the Hippo-independent HCT116 colon cancer xenograft model had no impact on tumor growth. This evidence concerns the gene YAP1 and malignant colon neoplasm.