TGFB2 and open-angle glaucoma: Given the body of evidence implicating TGF-β2 in the development of POAG9,12,19, we employed a TGFβ2-induced TM cell culture model to mimic the elevated TGF-β2 environment of POAG, therefore identifying differentially expressed genes and associated pathways that contribute to the pathogenesis of POAG in a hypothesis-independent and discovery-driven manner.