At the same time, other studies reported the opposite findings, suggesting that misfolded SOD1 is not found in spinal cords32–35, lymphoblasts36, or CSF37 from sALS patients. Whatever the cause of ALS pathogenesis, whether due to a mutant or wild type SOD1 protein, the outcome is the accumulation of misfolded SOD1 and possibly its amyloid aggregation tendency, which is highly toxic to motor neurons. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.