BMI1 and neoplasm: Consistent with these results, the growth of WaGa/tet-MUC1shRNA, but not WaGa/tet-CshRNA, tumor xenografts in NSG mice was inhibited by DOX treatment (Fig. 6B and Supplementary Fig. S9) and was associated with (i) downregulation of MUC1-C, MYCL, and BMI1, (ii) induction of DNA damage, as evidenced by increases in γH2AX, and (iii) apoptotic cell death, as supported by PARP1 cleavage (Fig. 6C).