Consistent with these results, the growth of WaGa/tet-MUC1shRNA, but not WaGa/tet-CshRNA, tumor xenografts in NSG mice was inhibited by DOX treatment (Fig. 6B and Supplementary Fig. S9) and was associated with (i) downregulation of MUC1-C, MYCL, and BMI1, (ii) induction of DNA damage, as evidenced by increases in γH2AX, and (iii) apoptotic cell death, as supported by PARP1 cleavage (Fig. 6C). This evidence concerns the gene MYCL and neoplasm.