CD4 and neoplasm: In addition, heterotopic tumors from CreERT2 mice showed diminished inflammation demonstrated by reduced presence of total leukocytes (CD45+ area), TAMs (CD68+ area), neutrophils (MPO+ cells), tumor-infiltrating lymphocytes, TILs (FOXP3+), as well as T regulatory cells, Tregs (FOXP3+CD4+ cells).