Moreover, to determine how the lack of IGF1R in the lung TME is mechanistically affecting tumor growth and metastasis, we performed double fluorescence immunostainings of p-IGF1R with CD31 (vascularization), Vimentin (fibroblast presence) and SMA (fibroblast activation) in lung sections from LLC-challenged mice. The gene discussed is IGF1R; the disease is neoplasm.