Second and most importantly, our analyses have shown that Tacstd2 is significantly upregulated in mouse lungs following infection with viral respiratory pathogens (SARS coronavirus, influenza virus, Sendai virus), but also non-viral pathogens including Mycobacterium tuberculosis, Streptococcus pneumoniae, and Aspergillus fumigatus, suggesting the involvement of Trop2 in the healing process and/or immune reactions. Here, TACSTD2 is linked to infection.