Three cases in our cohort (Patients 1, 2, and 3) were confirmed to have cryptic KMT2A insertions after a second review of karyotype analysis, which was based on the metaphase FISH analysis of KMT2A. This illustrates the need for FISH analysis using the KMT2A probe as an important auxiliary method to the CBA of AL patients. This evidence concerns the gene KMT2A and axial length measurement.