TP53 and myelodysplastic syndrome: Amplification of KMT2A could be defined as the presence of at least two extra gene copies as seven of 10 patients with AML and CK demonstrated ≥ 4 copies of KMT2A. Tang et al. reported that AML/MDS with KMT2A amplification is associated with a CK and high frequency of TP53 mutations8.