Translocations involving the lysine (K)-specific methyltransferase 2A gene (KMT2A), previously known as mixed lineage leukemia (MLL), are frequently associated with acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), and mixed-phenotype acute leukemia (MPAL)1. Here, KMT2A is linked to acute lymphoblastic leukemia.