TREX1 and systemic lupus erythematosus: Many genes which encode related proteins have been found potential candidates associated with SLE, such as DNase I, DNase­γ, DNase III and TREX1 involved in DNA clearance, C1q and C4 od the complement pathway and other functions (ACP5, AGS5, FASL and STING)51 and Fc receptors53.