Moreover, categorization by signal pathway revealed that Chronic myeloid leukemia, ErbB signal pathway, Glioma, Neurotrophin signaling pathway, PI3K-Akt signal pathway, Estrogen signal pathway and T cell receptor signal pathway were the hub enriched pathways (Fig. 5G and Table 7). This evidence concerns the gene BDNF and chronic myelogenous leukemia, BCR-ABL1 positive.