Many genes which encode related proteins have been found potential candidates associated with SLE, such as DNase I, DNase­γ, DNase III and TREX1 involved in DNA clearance, C1q and C4 od the complement pathway and other functions (ACP5, AGS5, FASL and STING)51 and Fc receptors53. This evidence concerns the gene SAMHD1 and systemic lupus erythematosus.