MYC amplification was verified to most commonly occur in mucosal and acral melanoma, with frequencies of 44.0% (11/25) and 40.0% (6/15) respectively, which were significantly higher than that in cutaneous melanoma (3/41, 7.3%, p = 0.001 and p = 0.008). The gene discussed is MYC; the disease is cutaneous melanoma.