In this study,Ding and colleagues recruited 36 temozolomide-resistant patients and 33 temozolomide-sensitive patients and found that circ-0072083 was increased in temozolomide-resistant glioma tissues and cells and that decreased expression of circ-0072083 blocked demethylation of ALKBH5, thereby reducing NANOG expression. Here, ALKBH5 is linked to central nervous system cancer.