Because PARP1 regulates myelination66 and tyrosinemia exhibits peripheral neuropathy and demyelination10, it will be of future interest to test if mutations of TyrRS that result in dominant-intermediate Charcot-Marie-Tooth neuropathy (DI-CMT)67 would modulate TyrRS-mediated PARP1 activation28. Here, YARS1 is linked to Charcot-Marie-Tooth disease, axonal, type 2FF.